Screening for Hepatocellular Carcinoma Recurrence After Liver Transplantation: Prospective Validation of Binary Criteria.

ABSTRACT:

Background

Many centers screen all recipients for hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). This approach may add substantial burdens of cost, incidental findings, and, depending on the imaging modality, radiation and/or contrast-induced complications. We created simple criteria to help clinicians identify low-risk patients in whom post-LT surveillance offers marginal utility.

Methods

Criteria were developed retrospectively using adults with HCC who underwent LT at the University of Cincinnati from 2000 to 2014. Low-risk patients had none of the following at LT: (1) outside Milan criteria, (2) alpha-fetoprotein ≥ 200 ng/mL, (3) prior hepatectomy with vascular invasion or unknown histology, and (4) any vascular invasion or > 3 lesions on expl

SUBMITTER: Dixon W 

PROVIDER: S-EPMC12664103 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature