Cross-Sectional Association of Ground-Level Ozone and Nitrogen Dioxide With Cardiac Mechanics Using Speckle-Tracking Echocardiography in the Cardiovascular Health Study.

ABSTRACT:

Purpose

Ground-level ozone (O₃) and nitrogen dioxide (NO₂) are two of the most important air pollutants, with accumulating evidence linking them to incident cardiovascular disease. The tissue-level mechanisms by which they affect myocardial function remain incompletely understood, however.

Methods

We applied speckle-tracking echocardiography (STE) to explore the relationship between chronic residential gaseous air pollution exposure and cardiac mechanics in community-dwelling older adults largely free of baseline heart disease. Average annual address-specific concentrations of O₃ and NO₂ were estimated from 1990 to 1994 using validated spatiotemporal models. The association between each pollutant and STE measures of left ventricula

SUBMITTER: Chang AY 

PROVIDER: S-EPMC12664112 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature