Joint association of urinary albumin-to-creatinine ratio within normal range and triglyceride-glucose index with incident cardiovascular disease: a prospective cohort study.

ABSTRACT:

Background

Elevated urinary albumin-to-creatinine ratio (UACR) within the normal range (< 30 mg/g) and the triglyceride-glucose (TyG) index are associated with cardiovascular disease (CVD) incidence, yet their joint effect remains underexplored.

Methods

This prospective cohort study used data from the 2016 Shandong-MOH Salt and Hypertension (SMASH) project, linked to CVD records until September 30, 2023, including 14,481 adults with normal UACR. Participants were stratified by TyG index and UACR quantiles. Multivariable Cox proportional hazards models and restricted cubic splines (RCS) were employed to evaluate individual and joint effects on overall CVD, coronary heart disease (CHD), and stroke. The incremental predictive value was assessed using the C-index, Net Reclassifi

SUBMITTER: Fengjun D 

PROVIDER: S-EPMC12664133 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature