Renal nerve stimulation modulates renal blood flow in a frequency-dependent manner.

ABSTRACT:

Background

Chronic overactivity of the renal nerves is a key pathophysiological attribute of drug-resistant hypertension. Indeed, catheter-based renal denervation can lower blood pressure by severing the brain-kidney (efferent nerves) and kidney-brain (afferent nerves) link, but its irreversibility and potential nerve reconnection limits adaptability and longevity, highlighting the need for alternative treatments. Kilohertz-frequency electrical stimulation is an approach known to reversibly inhibit peripheral nerve activity and has potential to reversibly modulate renal blood flow.

Methods

This study investigated how electrical stimulation of the renal nerves affects renal blood flow in a non-diseased anesthetized swine. Using unilateral hook electrodes around the renal arte

SUBMITTER: Kwaku D 

PROVIDER: S-EPMC12664136 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature