Pathogenic and transcriptomic differences among porcine reproductive and respiratory syndrome viruses from distinct lineages in piglets.

ABSTRACT: Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly recombinogenic pathogen that threatens global swine production. Multiple PRRSV lineages co-circulate in China, with lineage 1.8 being the predominant epidemic strain. However, the pathogenic characteristics and differences among strains from distinct lineages remain insufficiently studied. In this study, three novel recombinant PRRSV strains (GX-2428, GX-3264, and GX-5430) were isolated in Guangxi, China. Phylogenetic analysis of the ORF5 gene classified the three strains into lineage 3 (QYYZ-like), lineage 1.8 (NADC30-like), and lineage 1.5 (NADC34-like), respectively. Pathogenicity tests in piglets demonstrated that, compared with the control group, both GX-2428 and GX-3264 induced significant fever, whereas GX-5430

SUBMITTER: Tian L 

PROVIDER: S-EPMC12664146 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature