Neuromodulation effects of low-intensity transcranial focused ultrasound in human, a systematic review focusing on motor and sensory functions.

ABSTRACT:

Background

Low-intensity transcranial focused ultrasound (tFUS) has emerged as a novel non-invasive brain stimulation technique with therapeutic potential for various neurological conditions. However, its parameter-dependent bimodal neuromodulatory effects remain to be fully elucidated.

Objective

This study aims to review the evidence on tFUS-induced neuromodulation in humans, particularly its effects on motor and sensory functions, to identify specific stimulation parameters associated with excitatory and inhibitory outcomes, thereby informing future clinical applications.

Methods

A systematic review was conducted using Web of Science and PubMed, including primary interventional human studies on tFUS and neuromodulation published up to December 2024. Eligible studies

SUBMITTER: Ho HC 

PROVIDER: S-EPMC12664190 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature