Influenza vaccination and ischemic stroke risk reduction in elderly stroke survivors: a retrospective cohort study with negative control validation.

ABSTRACT:

Background and objectives

Stroke is a leading cause of disability and mortality among older adults, with high recurrence rates. Currently, there's limited research reporting on the protective effect of influenza vaccination against recurrent stroke in elderly stroke survivors. This study aimed to evaluate the association between influenza vaccination and stroke risk in this group.

Methods

A retrospective cohort study was conducted using data from the Ningbo Regional Health Information Platform. Eligible participants were adults aged ≥ 65 years with a history of stroke, registered in the platform for ≥ 1 year by December 31, 2021. Follow-up ended at stroke occurrence, death, or July 31, 2022, whichever occurred first. The primary outcome was any stroke event. Exposure was def

SUBMITTER: Yang T 

PROVIDER: S-EPMC12664219 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature