The SQUEEZE pilot trial: a trial to determine whether septic shock reversal is quicker in pediatric patients randomized to an early goal directed fluid-sparing strategy vs. usual care.

ABSTRACT:

Objective

The overall objective of our research is to determine in children with septic shock whether the use of a fluid-sparing strategy results in improved clinical outcomes without an increased risk of adverse events compared to usual care. The specific objective of this pilot randomized controlled trial was to evaluate the feasibility of a definitive multicenter trial to answer our research question.

Design

Pragmatic, 2-arm, parallel group, open-label, prospective pilot randomized controlled trial including a nested biosample-based translational study.

Setting

Pediatric tertiary care center.

Patients

Children aged 29 days to <18 years of age presenting to the emergency department or admitted to an inpatient ward (including the PICU) with suspected or confir

SUBMITTER: Parker MJ 

PROVIDER: S-EPMC12664234 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature