Antiphospholipid antibodies and subclinical interstitial lung disease in the MESA cohort.

ABSTRACT:

Background

Interstitial lung disease (ILD) is a rare complication of antiphospholipid syndrome (APS), but circulating antiphospholipid antibodies have been detected in patients with ILD without APS. Whether antiphospholipid antibodies are associated with subclinical ILD phenotypes is unknown. We aim to examine the associations between anticardiolipin (aCL) and B-2 glycoprotein-1 (B2GP1) isotypes and high attenuation areas (HAA) and interstitial lung abnormalities (ILA) on CT scans in the Multi-Ethnic Study of Atherosclerosis (MESA).

Methods

We measured serum aCL and B2GP1 isotypes and calculated proportion of HAA on cardiac CT scan in 6623 MESA participants at baseline. The presence of ILAs were assessed on full lung CT scans at Exam 5. We used linear and logistic regression

SUBMITTER: McGroder CF 

PROVIDER: S-EPMC12664236 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature