Association between the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and 28-day mortality in neurocritical care patients: a retrospective cohort study based on the MIMIC-IV database.

ABSTRACT:

Background

In recent years, reliable prognostic markers are increasingly important in neurocritical care. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score, a composite biomarker reflecting systemic immune-nutritional status, has shown promise as a predictor. This study aims to evaluate the prognostic value of the HALP score for predicting 28-day mortality in neurocritical care unit (NCCU) patients.

Materials and methods

We conducted a retrospective cohort study by identifying neurocritical care patients from the MIMIC-IV database. The association between the HALP score and 28-day mortality was primarily assessed using multivariable Cox proportional hazards regression. Multiple analytical approaches were employed to comprehensively examine this relationship, inc

SUBMITTER: Zou Y 

PROVIDER: S-EPMC12664272 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature