Epigenome-wide DNA methylation profiling reveals risk genes for migraine and its subtypes.

ABSTRACT:

Background

Migraine is a highly disabling neurovascular disorder, yet its underlying molecular mechanisms remain incompletely understood. Emerging evidence implicates epigenetic modifications, particularly DNA methylation, in migraine pathophysiology, but whether these changes play a causal role has not been established.

Methods

We integrated large-scale brain and blood methylation quantitative trait loci (mQTL) datasets with genome-wide association study (GWAS) data to investigate the causal role of DNA methylation in migraine and its subtypes. Two-sample Mendelian randomization (MR) was applied to evaluate the effects of cytosine-phosphate-guanine (CpG) methylation on migraine risk. Significant CpG sites were annotated to genes and refined through a multi-step prioritizati

SUBMITTER: Liu M 

PROVIDER: S-EPMC12664279 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature