Unlocking the Antioxidant, Enzyme Inhibitory and Acaricidal Potential of <i>Azadirachta indica</i> Phytoconstituents Using In Vitro and In Silico Approaches.

ABSTRACT: The study evaluated the acaricidal potential of bioactive components of Azadirachta indica against scabies mortality using both in vitro and in silico approaches. Sarcoptes scabiei were stimulated with A. indica at four concentrations (25-100 mg/mL) at different intervals. The study assessed the cytotoxic, neuroactive, and detoxification-modulating potential of A. indica, emphasizing their antibacterial, antioxidant, and enzyme-inhibitory potential. LCMS was used for the characterization of phytoconstituents. In silico analysis encompassed target prediction, toxicity assessment, biological activity prediction, protein structure modeling, and gene expression analysis. Molecular docking assesses the binding affinities of bioactive components, and the ExPASy databa

SUBMITTER: Fatima T 

PROVIDER: S-EPMC12664285 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature