In Vitro and In Vivo Evaluation of Rosuvastatin and Momordica charantia (Bitter Melon) Extract: Pharmacokinetic Interactions and Anticancer Potential.

ABSTRACT:

Objective

This study investigates the pharmacokinetic interactions and anticancer potential for rosuvastatin in combination with Momordica charantia (M. charantia) extract through both in vitro and in vivo models.

Methods

A validated high-performance liquid chromatography (HPLC) method (R² = 0.9983) was used to quantify rosuvastatin plasma levels. In vivo pharmacokinetic parameters were assessed in Wistar rats following oral administration of rosuvastatin, M. charantia extract, and their combination. In vitro, HepG2 liver cancer cells were treated with rosuvastatin, M. charantia, and their combination to evaluate anticancer activity. The half-maximal inhibitory concentration (IC₅₀) and fractional inhibitory concentration (FIC) were calculated to assess cytotoxic effects and

SUBMITTER: Akeel R 

PROVIDER: S-EPMC12664286 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature