Causal relationships of serum iron metabolites with sepsis and cardiomyopathy: a Mendelian randomization analysis.

ABSTRACT:

Objective

The study aims to investigate the causal relationships of serum iron (SI) metabolites with sepsis and cardiomyopathy as two distinct outcomes.

Methods

Genome-wide association studies (GWAS) data for SI, serum ferritin (SF), serum transferrin (STF), transferrin receptor (TFRC), sepsis, and cardiomyopathy were obtained from the EBI website. Transferrin saturation percentage (TSP) data were from the Genetics of Iron Status Consortium. Due to lack of GWAS for acute sepsis-induced cardiomyopathy (SIC), cardiomyopathy GWAS was used as a genetic proxy. Causal relationships were analysed using inverse-variance weighting, MR-Egger, weighted median, simple mode, and weighted mode methods. Power calculations, Cochran's Q test, MR-PRESSO, and Steiger directionality test were p

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12664298 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature