Divergent roles of c-Src in controlling platelet-derived growth factor-dependent signaling in fibroblasts.

ABSTRACT: The vast complexity of platelet-derived growth factor (PDGF)-induced downstream signaling pathways is well known, but the precise roles of critical players still elude us due to our lack of specific and temporal control over their activities. Accordingly, although Src family members are some of the better characterized effectors of PDGFbeta signaling, considerable controversy still surrounds their precise functions. To address these questions and limitations, we applied a chemical-genetic approach to study the role of c-Src at the cellular level, in defined signaling cascades; we also uncovered novel phosphorylation targets and defined its influence on transcriptional events. The spectacular control of c-Src on actin reorganization and chemotaxis was delineated by global substrate labeling

SUBMITTER: Shah K 

PROVIDER: S-EPMC1266437 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature