Congenital heart disease in men of reproductive age: Nationwide cohort studies of prevalence, male fertility, and birth outcomes in offspring.

ABSTRACT:

Background

The potential for men with congenital heart disease (CHD) to father children and the impact of paternal CHD on offspring birth outcomes are not well understood.

Methods

Using Norwegian nationwide registries from 1994 to 2014, we identified two study populations: 1 829 877 men aged 18-50 years and 1 207 410 newborns. First, we reported the time trends of CHD in men and paternal CHD in newborns. Second, we compared the rate of becoming fathers in men with and without CHD. Third, we compared birth outcomes in offspring with and without paternal CHD.

Results

Between 1994 and 2014, the prevalence of CHD in men of reproductive age increased from 22.7 to 32.2 per 10 000, while the prevalence of paternal CHD in newborns increased from 21.6 to 26.9 per 10 000. Men w

SUBMITTER: Sandberg M 

PROVIDER: S-EPMC12664383 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature