Radical Prostatectomy Combined with Prostate Specific Membrane Antigen-radioguided Lymph Node Dissection is Associated with Longer Treatment-free Survival for Patients with Primary Lymph Node-positive Prostate Cancer.

ABSTRACT:

Background and objective

The optimal treatment for patients with prostate cancer with primary lymph node metastases (LNMs) is still a matter of debate. Radical prostatectomy (RP) combined with prostate-specific membrane antigen (PSMA)-radioguided surgery (RGS) may be a helpful technique in removal of LNMs detected on preoperative PSMA positron emission tomography (PET) in comparison to conventional lymph node dissection (LND). The aim of our retrospective analysis was to determine whether addition of PSMA-RGS at primary radical prostatectomy (RP) is associated with longer survival.

Methods

^99mTechnetium-PSMA-I&S was administered preoperatively to facilitate LND during RP in the RGS group. Standard descriptive statistics were used to outline differences in patient

SUBMITTER: Korn P 

PROVIDER: S-EPMC12664431 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature