From adaptive to maladaptive hippocampal resting-state functional connectivity over the course of multiple sclerosis to understand memory impairment.

ABSTRACT:

Background

It remains unclear how resting-state functional connectivity (rsFC) changes in the hippocampus modulate the negative impact of white matter (WM) lesions on memory performance over the course of multiple sclerosis (MS). This study investigates whether hippocampal rsFC alterations at each MS clinical stage affect memory performance.

Methods

This cross-sectional study included 109 individuals: 30 healthy controls and 79 patients (20 with clinically or radiologically isolated syndrome (CIS-RIS), 24 with relapsing-remitting MS (RRMS) and 35 with progressive MS (PMS)). Verbal memory was assessed using a modified Rey's Auditory Verbal Learning Test. Magnetic resonance imaging measured WM lesions and hippocampal rsFC. Between-group memory differences were analyzed using l

SUBMITTER: Salavedra-Pont J 

PROVIDER: S-EPMC12664432 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature