Radio-magnetic dual-functional microspheres for magnetic hyperthermia therapy combined with radioembolization of hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) remains a formidable clinical challenge due to its aggressive nature, high recurrence rate, and limited therapeutic options, particularly for intermediate-advanced stage patients who are ineligible for surgical resection. Current transarterial chemoembolization (TACE) and conventional transarterial radioembolization (TARE) often face challenges such as incomplete tumor necrosis and radioresistance. To address these critical clinical issues, we develop an innovative polydopamine-coated ¹⁷⁷Lu-labeled magnetic microspheres (¹⁷⁷Lu-MMS@PDA) that synergistically combines TARE with magnetic hyperthermia therapy (MHT), which enable non-invasive, deep-tissue-penetrating hyperthermia while significantly enhancing radiostability. This dual-modality

SUBMITTER: Wu M 

PROVIDER: S-EPMC12664441 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature