A double-blind, controlled trial of circadian effective light therapy in patients with Parkinson's disease.

ABSTRACT: Despite current medical therapy for Parkinson's Disease (PD), many experience persistent motor symptoms and significant unmanaged non-motor issues. Previous studies suggest that light therapy (LT) provides benefits for motor and non-motor features of PD. This study evaluated Circadian Effective LT (CELT) with a spectral band between 460 and 545 ​nm for the motor and non-motor features of PD. We conducted a multi-center, randomized, double-blind, controlled clinical trial of CELT in people with Parkinson's disease on standard-of-care therapy. Ninety-two participants (45 active, 47 control) were randomized 1:1 to active or control CELT for 1 ​h each evening for 6 months. Patients were evaluated in their 'ON state'. The mean (SE) change on the primary endpoint of the MDS-UPDRS parts 1-3 was -

SUBMITTER: Wyman BT 

PROVIDER: S-EPMC12664443 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature