R-spondin 2 suppresses hepatic steatosis via activation of AMPK-ACC signaling.

ABSTRACT:

Background & aims

Metabolic dysfunction-associated steatotic liver disease (MASLD) primarily results from dysregulated lipid metabolism in hepatocytes. However, the mechanisms governing hepatic lipid metabolism remain incompletely understood. Our preliminary experiments demonstrated elevated expression of R-spondin 2 (RSPO2), a matricellular protein, in steatotic livers. Therefore, we investigated the role of RSPO2 in MASLD and potential underlying mechanisms.

Methods

Comprehensive in vivo and in vitro studies were performed to investigate the role of RSPO2 in steatosis. Unbiased transcriptomic analyses of hepatic RNA samples were conducted to identify RSPO2-regulated signaling pathways. To examine the in vivo role of Rspo2, both hepatocyte-specif

SUBMITTER: Aithabathula RV 

PROVIDER: S-EPMC12664473 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature