Bioinspired honeycomb-mimetic adaptive hyaluronic acid hydrogel composite scaffold: intelligent prevention and treatment of infection of bone implants and promotion of bone repair.

ABSTRACT: Addressing two major challenges in the field of bone implants: bacterial infection and delayed bone fusion, this study draws inspiration from the beehive structure to develop an adaptive enzyme-responsive hydrogel composite scaffold. The scaffold composed of an intermittently 3D low-temperature deposition printing honeycomb-shaped Poly(lactic-co-glycolic acid)/β-tricalcium phosphate icaritin (PTI) outer layer, maintaining the mechanical strength(elastic modulus ∼0.8 MPa) and osteogenic activity required for bone defect repair. Its core encapsulates hyaluronic acid (HA) hydrogel loaded with vancomycin(Van), serving as an intelligent "enzyme-responsive" unit. This core design utilizes bacterial-secreted hyaluronidase (HAase) at the infection site as a trigger signal, enabling on-demand, inte

SUBMITTER: Fu J 

PROVIDER: S-EPMC12664479 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature