Improving quantitative susceptibility mapping for the identification of traumatic brain injury neurodegeneration at the individual level.

ABSTRACT:

Background

Emerging evidence suggests that traumatic brain injury (TBI) is a major risk factor for developing neurodegenerative disease later in life. Quantitative susceptibility mapping (QSM) has been used by an increasing number of studies in investigations of pathophysiological changes in TBI. However, generating artefact-free quantitative susceptibility maps in brains with large focal lesions, as in the case of moderate-to-severe TBI (ms-TBI), is particularly challenging. To address this issue, we utilized a novel two-pass masking technique and reconstruction procedure (two-pass QSM) to generate quantitative susceptibility maps (QSMxT; Stewart et al., 2022, Magn Reson Med.) in combination with the recently developed virtual brain grafting (VBG) procedure for brain repair (Radwa

SUBMITTER: Dominguez D JF 

PROVIDER: S-EPMC12664505 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature