SLC7A11-independent disulfidptosis induced by a two-pronged delivery strategy for bladder cancer chemotherapy and cisplatin-resistance reverse.

ABSTRACT: The intracellular overload of disulfide is induced by the imbalance between cystine (Cys) uptake and intracellular Cys reduction, leading to disulfidptosis. Solute carrier family 7 member 11 (SLC7A11) is a Cys transporter at the cell surface, and its high level of expression, together with glucose deprivation, is a requisite determining the disulfidptosis induction. Recent studies have exploited glucose deprivation by multifunctional nanomaterials as mainstream to evoke disulfidptosis, unfortunately with a strong bias to SLC7A11 highly expressed tumors. Despite many efforts to modulate SLC7A11 expression, the uncertainty brought by complex biological mechanisms under different exposure inspired us to find a more solid approach to raise Cys-uptake efficiency. In this study, we developed a t

SUBMITTER: Zheng B 

PROVIDER: S-EPMC12664518 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature