Mapping human thalamocortical connectivity with electrical stimulation and recording.

ABSTRACT: The brain's functional architecture is shaped by electrophysiological interactions between its components, encompassing both cortical and subcortical structures. In this study, we provide an atlas of electrophysiological causal connections across 4,864 brain sites in 27 human participants using repeated single-pulse electrical stimulations and recordings with intracranial electrodes implanted in cortical regions and multiple thalamic nuclei. We show distinct spectral signatures elicited by perturbations of specific brain areas. Identified features of causal connectivity exhibited highly organized yet distinct patterns, indicating that each feature may correspond to a separate mode of information transmission across brain regions. Notably, we report a new waveform with unique temporal and s

SUBMITTER: Lyu D 

PROVIDER: S-EPMC12664536 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature