Metabolomics and lipidomics study on serum metabolite signatures in Alzheimer's disease and mild cognitive impairment.

ABSTRACT: Alzheimer's disease (AD) and mild cognitive impairment (MCI) are major causes of dementia in the elderly, with metabolic alterations not fully understood. In this study, we quantitatively profiled serum metabolites of participants in 2 independent cohorts. Based on the data from cohort 1 (22 AD patients, 19 MCI patients and 19 cognitively normal participants (CN)), we identified 32 differential metabolites in AD and 49 in MCI serum. Notably, differential metabolites related to amino acid (AA), organic acid, fatty acid (FA), phosphatidylcholine (PC), sphingomyelin (SM) metabolism in AD and free fatty acid (FFA), acylcarnitine, PC, SM in MCI were strongly associated with cognitive level, memory, attention and execution function as evaluated by cognitive scales. Pathway analysis based on the

SUBMITTER: Mai Y 

PROVIDER: S-EPMC12664555 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature