TNFR2 signaling shapes the sex-specific remyelinating properties of microglia after experimental stroke.

ABSTRACT: Microglial tumor necrosis factor receptor 2 (TNFR2) has emerged as a critical modulator of neuroinflammation and repair following ischemic stroke. Here, we investigated the sex-specific role of TNFR2 in regulating microglial responses during the acute and subacute phases after stroke. Using a conditional knockout model, we found that TNFR2 ablation in microglia exerted opposite effects on morphology, reactivity, and phagocytic capacity in female compared to male mice at day 5 post-stroke. In females, TNFR2 deletion impaired microglial reactivity and myelin debris clearance, reduced oligodendrocyte maturation, and worsened motor and cognitive recovery. In contrast, TNFR2 ablation in males produced milder and occasionally opposing effects, without affecting functional outcomes. Analysis of c

SUBMITTER: Raffaele S 

PROVIDER: S-EPMC12664556 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature