Impact of Age and Sex on Coronary Flow Reserve and Microvascular Function in Patients With Angina and Nonobstructive Coronary Arteries.

ABSTRACT:

Background

Angina and nonobstructive coronary arteries is increasingly recognized, but the impact of age and sex on coronary microvascular function in this population has received limited study.

Methods

In 206 consecutive patients with angina and nonobstructive coronary arteries, invasive coronary function testing was performed including vasoreactivity testing with acetylcholine provocation, guidewire-based assessment of coronary flow reserve (CFR) with bolus thermodilution, and index of microcirculatory resistance (IMR). Multivariable regression models assessed associations of age and sex with coronary physiologic indices, and subgroup analyses were conducted to examine age-related trends in microvascular function separately in men and women.

Results

Mean age was 57.

SUBMITTER: Kostantinis S 

PROVIDER: S-EPMC12664592 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature