Integrated analysis of DNA methylation and transcriptome profiles in broiler heart and lung tissues reveals epigenetic regulatory mechanisms underlying ascites syndrome.

ABSTRACT: Ascites syndrome (AS), a prevalent nutritional and metabolic disorder in broilers, causes substantial economic losses to the poultry industry. However, its comprehensive molecular mechanisms, particularly the interplay between epigenetic regulation and transcriptional dynamics, remain incompletely elucidated. This study compared AS broilers and normal broilers by routine hematological examinations and blood gas indicators. These analyses revealed significant abnormalities in AS broilers. Histological examination of myocardial tissue using HE staining revealed cardiac tissue damage in AS broilers. To investigate the underlying mechanisms, an integrated multi-omics analysis was performed using whole genome bisulfite sequencing and transcriptome data. This approach identified 891 genes in hea

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12664601 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature