Effects of individualized rTMS on functional connectivity related to the default mode network and frontal-parietal network in major depressive disorder: exploratory analysis of a randomized controlled trial.

ABSTRACT:

Objective

Repetitive transcranial magnetic stimulation (rTMS) has been shown to alleviate depressive and anxiety symptoms in patients with major depressive disorder (MDD), typically by targeting the dorsolateral (DLPFC) or dorsomedial prefrontal cortex (DMPFC). Based on a pre-registered randomized controlled trial, this study presents an exploratory neuroimaging analysis investigating the impact of rTMS targeting the DLPFC versus the DMPFC on functional connectivity with the default mode network (DMN) and frontal-parietal network (FPN) in patients with MDD.

Methods

Sixty-four MDD patients were randomly assigned to DLPFC-rTMS (n = 36) or DMPFC-rTMS (n = 28) groups for a 21-day intervention. Symptoms were evaluated with Hamilton Depression Rating Scale (HAMD) and Hamilton Anxi

SUBMITTER: Jin J 

PROVIDER: S-EPMC12664640 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature