A CSF Background Suppression Scheme in Arterial Spin Labeling MRI.

ABSTRACT: Arterial spin labeling (ASL) MRI suffers from low signal-to-noise ratio. Current background suppression (BS) methods focus on suppressing tissue signal. The present work aims to test the hypothesis that BS schemes to suppress CSF signal can produce a greater benefit, given the recent observations that water in CSF has more pulsation as part of the neurofluid circulation. We developed a CSF BS scheme that maximally suppresses residual CSF signal using two inversion pulses. Its performance was compared with regular BS and enhanced BS, both of which primarily suppress gray and white matter signals. All schemes were evaluated in single-delay and multi-delay pseudo-continuous ASL (pCASL) MRI. The single-delay scans assessed cerebral blood flow (CBF), while the multi-delay scans measured both CB

SUBMITTER: Hu Z 

PROVIDER: S-EPMC12664665 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature