Age-Related Changes in Default Mode Network in Autism Spectrum Disorder: Insights From Effective Connectivity.

ABSTRACT: Altered brain connectivity in the default mode network (DMN) has frequently been reported in Autism Spectrum Disorder (ASD) patients compared to typically developing control (TC) participants. Most of these studies have focused on a specific age group or mixed-age groups with ASD. This study investigates age-related changes in effective connectivity (EC) within the DMN in individuals with ASD compared to TC. Using resting-state functional magnetic resonance imaging (MRI) data from the ABIDE-I and ABIDE-II databases, we analyzed 591 ASD and 725 TC participants across three age cohorts: children (≤ 12 years), adolescents (12-18 years), and adults (≥ 18 years). Spectral Dynamic Causal Modeling was employed to estimate EC within the DMN, focusing on eight regions of interest: posterior cingula

SUBMITTER: Shafieizadegan S 

PROVIDER: S-EPMC12664775 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature