ATP-binding cassette B8 prevents endothelial dysfunction and atherosclerosis.

ABSTRACT: ATP-binding cassette B8 (ABCB8) is a mitochondrial iron exporter known to prevent iron-dependent oxidative stress in cardiomyocytes and endothelial cells. However, the role of ABCB8 in endothelial and vascular function remains unclear. Here, we identified ABCB8 as a key regulator of vascular homeostasis. We found that loss of ABCB8 in endothelial cells triggers a pro-inflammatory transcriptional program, marked by upregulation of TGF-β isoforms and activation of TGF-β signalling. We show that TGF-β functions as an iron effector that drives mitochondrial reactive oxygen species (ROS) and mitochondrial damage, revealing a new ABCB8-iron-TGF-β axis in endothelial cells. In endothelial-specific inducible Abcb8 knockout mice (Abcb8^ECKO), ABCB8 deficiency leads to endothelial activati

SUBMITTER: Chaker AB 

PROVIDER: S-EPMC12664813 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature