Glucocorticoids Modulate Expression of Perineuronal Net Component Genes and Parvalbumin During Development of Mouse Cortical Neurons.

ABSTRACT: Severe prenatal maternal stress is a risk factor for schizophrenia in offspring. Since parvalbumin-containing GABAergic interneuron function in the cortex and hippocampus is compromised in schizophrenia, and perineuronal nets (PNNs) facilitate the functioning of these cells, we tested the hypothesis that glucocorticoids, as stress mediators that can access the foetal compartment, might influence the expression of PNN component genes. In cultured mouse cortical neurons, we detected effects of hydrocortisone on many PNN component genes, via diverse mechanisms. A rapid (< 4 h), glucocorticoid receptor (GR)-mediated suppression of neurocan and hyaluronan synthase (Has) 1 and 3 mRNAs was observed at 7 days in vitro (DIV), whereas at 14 DIV, brevican and versican expression was reduced by hydroc

SUBMITTER: Yue L 

PROVIDER: S-EPMC12664862 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature