Sex-specific risk prediction models for aneurysmal subarachnoid hemorrhage-A UK Biobank study.

ABSTRACT:

Background

We recently developed and validated the SMA²SH²ERS risk prediction model for aneurysmal subarachnoid hemorrhage (ASAH) in the general population (c-statistic 0.62; 95% confidence interval [CI] 0.60-0.64). Given that women have higher ASAH incidence than men, and that predictors for ASAH have different effect sizes between sexes, we developed sex-specific risk prediction models.

Methods

Data from the prospective UK Biobank Study were used for model development. Participants with ASAH (per hospital-based ICD codes) before baseline or with missing predictor data were excluded. We developed multivariable Cox proportional hazards models for women and men separately to study the association between earlier recognized SMA²SH²ER

SUBMITTER: Rissanen I 

PROVIDER: S-EPMC12664918 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature