Neuroinflammation in long-term cognitive impairment after aneurysmal subarachnoid hemorrhage.

ABSTRACT:

Background

Survivors of aneurysmal subarachnoid hemorrhage (aSAH) often have cognitive impairment, which may be caused by long-term inflammation. We aimed to determine whether long-term neuroinflammation or microstructural brain damage is associated with cognitive impairment after aSAH.

Methods

In this prospective cohort study, we included patients >3 years after aSAH between 2020 and 2022. Patients underwent neuropsychological evaluation, translocator protein 18 kDA (TSPO) positron emission tomography (PET) imaging using [¹⁸F]DPA-714 to determine neuroinflammation, and brain diffusion kurtosis imaging (DKI) to determine microstructural damage. We compared TSPO PET binding potential, mean kurtosis (MK), kurtosis anisotropy (KA), axial kurtosis (AK), and radial kur

SUBMITTER: Tack RW 

PROVIDER: S-EPMC12664920 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature