Erythropoietin promotes cell proliferation in Neuro-2A mouse neuroblastoma cells.

ABSTRACT: Erythropoietin (Epo) is a glycoprotein hormone primarily known for regulating red blood cell production. Beyond erythropoiesis, Epo has been reported to exert tissue-protective effects, including neuroprotective and neuroregenerative properties. While its erythropoietic activity is mediated by the Epo receptor (EpoR), its tissue-protective function has been suggested to involve alternative receptor(s), the existence of which remains unclear. To investigate the effects of Epo on neuronal cell growth and explore potential tissue-protective receptors in the future, we stably expressed the human EPO gene in the mouse neuroblastoma cell line Neuro-2A (N2A) and hippocampal neuronal cell line HT22 and investigated the effects of Epo overexpression on neuronal cell proliferation. ELISA and

SUBMITTER: Kittur FS 

PROVIDER: S-EPMC12664986 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature