Clinical and immunological long-term outcomes after autologous hematopoietic stem cell transplantation in systemic sclerosis: a retrospective single-center experience.

ABSTRACT:

Background

Severe forms of systemic sclerosis (SSc) can be treated with autologous hematopoietic stem cell transplantation (aHSCT), but transplant-related mortality (TRM) can be considerable.

Objectives

To describe the long-term outcomes after aHSCT with a focus on clinical and immunological parameters.

Design

Retrospective single-center cohort study.

Methods

The overall survival, course of skin fibrosis and lung function, need for immunosuppressive treatments, and immunophenotyping with flow cytometry of peripheral blood of SSc patients after aHSCT were analyzed.

Results

Thirty-three patients were included with a mean follow-up time of 7.0 years (maximum 15.7 years). TRM was 6.1%, and seven deaths occurred during follow-up. Skin fibrosis improved, and l

SUBMITTER: Gernert M 

PROVIDER: S-EPMC12665003 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature