Pan-Cancer Analysis of the Prognostic and Immunological Role of ECT2: A Promising Target for Survival and Immunotherapy.

ABSTRACT:

Objectives

The aim of this study is to investigate the role of epithelial cell transforming sequence 2 (ECT2) as a pan-cancer biomarker and to assess its potential as an immune-related target for cancer immunotherapy.

Methods

We conducted a comprehensive analysis of ECT2 expression across 44 tumor types using large-scale transcriptomic datasets from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) project. Pan-cancer Cox regression analyses were performed to evaluate the correlation between ECT2 expression and patient survival outcomes. Functional assays, including ECT2 knockdown via shRNA in the HepG2 hepatocellular carcinoma (HCC) cell line, were employed to investigate its mechanistic role. Transcriptomic profiling and pathway analyses were also co

SUBMITTER: Wang L 

PROVIDER: S-EPMC12665020 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature