Aquilaria sinensis MYB-Like Transcription Factor AsMYB1 Promotes 2-(2-Phenylethyl)Chromone Biosynthesis Through Interacting With 14-3-3 Family Protein AsGRF1.

ABSTRACT: 2-(2-Phenylethyl)chromones (PECs) are the primary constituents of agarwood, a valuable aromatic resin widely used in traditional oriental medicine and incense production, exhibiting diverse pharmacological activities. While we have previously reported a polyketide synthase (AsPECPS) playing a crucial role in the biosynthesis of PECs in agarwood, the intrinsic regulatory mechanisms underlying PEC biosynthesis remain largely elusive. Here, we successfully characterised a new 1R-subtype myeloblastosis (MYB) transcription factor (AsMYB1) from Aquilaria sinensis whose expression is significantly induced under salt treatment. Further overexpression, RNA interference (RNAi) and gene-editing experiments confirmed the positive regulatory role of AsMYB1 in PEC biosynthesis. AsMYB1 specifically bound

SUBMITTER: Mi X 

PROVIDER: S-EPMC12665066 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature