Tumoral Stage of Mycosis Fungoides, Misdiagnosed With Wells Syndrome and Langerhans Cell Histiocytosis Histologically: A Challenging Case and Review of the Literature.

ABSTRACT:

Background

Mycosis fungoides (MF) is a type of cutaneous T-cell lymphoma (CTCL) with slow progression, usually presenting with patches and plaques. The infiltration of histiocytes and eosinophils in skin cancers can mask the underlying condition, posing a diagnostic challenge. While cases of MF associated with tissue eosinophilia or histiocytosis infiltration resembling Langerhans cell histiocytosis (LCH) have been reported, the simultaneous occurrence of both conditions in a single MF patient has not been documented.

Case

In this case report, we presented an elderly man with a known history of patch and plaque-stage MF who developed a large cutaneous tumor on his right mandibular margin. Multiple biopsies initially led to misdiagnoses, attributing the lesion to Well's syndr

SUBMITTER: Vahabi SM 

PROVIDER: S-EPMC12665118 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature