Clinical Outcomes in Patients With CLL Treated With BTKi at a Large US Cancer Center.

ABSTRACT: Patients with chronic lymphocytic leukemia (CLL) treated with covalent Bruton's tyrosine kinase inhibitors (BTKi) eventually discontinue treatment, but data on outcomes post-BTKi treatment discontinuation are limited. In this single-institution, retrospective chart review of 104 adult patients with CLL treated with a covalent BTKi between July 2011 and April 2019 and who subsequently discontinued for any reason, the majority of patients (59.9%) received the index BTKi in their first (27.5%) or second (32.4%) line of therapy. Median progression-free survival (PFS) from index BTKi initiation was 3.2 years, and median overall survival (OS) was 8.9 years. There was a notable correlation between PFS and OS (r = 0.79). Following the discontinuation of their last BTKi treatment, over half

SUBMITTER: Lin KH 

PROVIDER: S-EPMC12665162 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature