Associations Between Hiccups and Subsequent Cancer Diagnoses: A Population-Based Cohort Study.

ABSTRACT:

Background

Several case reports have recounted hiccups as a possible symptom of cancer, but potential associations in large study samples have not been examined.

Methods

This population-based cohort study examined associations between hiccups and subsequent cancer diagnoses. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated.

Results

Of 8466 patients diagnosed with hiccups during the study period (1997-2018), 7531 (89.0%) were men, 4013 (47.4%) were diagnosed in primary healthcare, and 325 (3.8%) were diagnosed with cancer. In men, hiccups were associated with nervous system (SIR 1.94; 95% CI, 1.08-3.20), hematologic (1.52; 1.17-1.93), and gastrointestinal (1.61; 1.36-1.89) cancers, including esophageal (2.63; 1.47-4.43), stomach (

SUBMITTER: Jansaker F 

PROVIDER: S-EPMC12665188 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature