Re-biopsy and modified biopsy in mosaic human embryos with simple segmental chromosomal deletion.

ABSTRACT:

Background

There is a considerable proportion of false positive results when the result of preimplantation genetic testing for aneuploidy is chromosomal mosaicism. The aim of this study was to assess the concordance among clinical trophectoderm biopsy, second trophectoderm biopsy, and inner cell mass biopsy in mosaic human embryos with segmental deletion and evaluate a modified biopsy protocol.

Methods

This retrospective study included 100 pretested blastocysts, which were classified as segmental deletion mosaics with one to two chromosomes were affected, donated by 84 couples in a single, high-volume fertility center in Beijing China. Re-biopsy was taken from the inner cell mass and two symmetrical trophectoderm sites near the inner cell mass in each embryo. Samples from th

SUBMITTER: Wang W 

PROVIDER: S-EPMC12665203 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature