Prevalence and predictors of low bone mineral density in pediatric inflammatory bowel disease.

ABSTRACT:

Objectives

Bone health is at risk in children with inflammatory bowel disease (IBD). This study examined the prevalence and predictors of low bone mineral density (BMD) in a cohort of children and young adults with IBD.

Methods

This single-center retrospective study included patients with IBD, ages 3.5-22 years, with completed dual x-ray absorptiometry (DXA) scans from 2006 to 2019. Demographic, clinical, and laboratory data were collected. Logistic regression analysis identified predictors associated with low BMD (Z-scores ≤ -2 standard deviations [SDs]) for three outcomes. In an overlapping IBD cohort with available genetic data between 2002 and 2019 (n = 378), genetic risk for diminished bone health was calculated using published polygenic risk scores generated from genom

SUBMITTER: Rudra S 

PROVIDER: S-EPMC12665282 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature