Surgical restabilization reduces the progression of post-traumatic osteoarthritis initiated by ACL rupture in mice.

ABSTRACT:

Objective

People who sustain joint injuries such as anterior cruciate ligament (ACL) rupture often develop post-traumatic osteoarthritis (PTOA). In human patients, ACL injuries are often treated with ACL reconstruction. However, it is still unclear how effective joint restabilization is for reducing the progression of PTOA. The goal of this study was to determine how surgical restabilization of a mouse knee joint following non-invasive ACL injury affects PTOA progression.

Design

In this study, 187 mice were subjected to non-invasive ACL injury or no injury. After injury, mice underwent restabilization surgery, sham surgery, or no surgery. Mice were then euthanized on day 14 or day 49 after injury/surgery. Functional analyses were performed at multiple time points to assess v

SUBMITTER: Lin YY 

PROVIDER: S-EPMC12665346 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature