An anion-binding approach to enantioselective photoredox catalysis.

ABSTRACT: Photoredox catalysis has emerged as a transformative strategy in synthetic chemistry, enabling a wide variety of valuable chemical reactions through generation of highly reactive radical ion intermediates. Pairing chiral counteranions with cation radical intermediates provides a potentially generalizable tool for controlling absolute stereochemistry in various reactivity contexts. However, ion-pairing effects on the efficiency of photoinduced processes and the reactivity of radical ion pairs impose severe limits on the chiral anions that can be engaged effectively. In this study, we report that association of neutral chiral small-molecule hydrogen-bond donors with the counteranions of cation radical intermediates can achieve enantioselectivity through ion-pairing and other noncovalent inte

SUBMITTER: Vojackova P 

PROVIDER: S-EPMC12665365 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature