Renoprotective Role and Mechanisms of Luteolin in Chronic Kidney Disease: Insights From NHANES Data, Network Pharmacology, Mendelian Randomization, and Molecular Docking Techniques.

ABSTRACT: Although the renoprotective properties of flavonoids are well established in chronic kidney disease (CKD), further investigation is required to identify the most efficacious compound of flavonoids and to elucidate the underlying mechanisms. This study identified the most advantageous compound of flavonoids for CKD using data from the National Health and Nutrition Examination Survey (NHANES) database and investigated underlying mechanisms through mediation analysis, network pharmacology, bioinformatics analysis, Mendelian randomization (MR), and molecular docking techniques. Our research discovered that flavones, including luteolin and apigenin, played a crucial role in reducing the risk of CKD. The intake of apigenin, luteolin, and total flavones was all significantly associated with the r

SUBMITTER: Li M 

PROVIDER: S-EPMC12665478 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature