Automated contouring, treatment planning, and quality assurance for total marrow lymphoid irradiation.

ABSTRACT:

Purpose

Total marrow and lymphoid irradiation (TMLI) enables dose escalation to targets while minimizing exposure to surrounding organs at risk (OARs), but its clinical implementation is complex. To simplify this process, contouring, treatment planning, and physics plan checks were automated, and the scripts were made publicly available.

Methods

Fifty patients (age, range 2-64 years) previously treated with volumetric modulated arc therapy total body irradiation (VMAT-TBI) were used for the development of an auto-contouring model to segment the relevant targets. Auto-contours were evaluated using the Dice Similarity Coefficient (DSC), 95% Hausdorff Distance (HD95), and qualitative ranking by four physicians. Automated planning script was created using the Varian Eclipse TPS

SUBMITTER: Simiele E 

PROVIDER: S-EPMC12665524 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature