Evolutionary conservation of dopamine-mediated cellular plasticity in Arctic sponges (Porifera).

ABSTRACT: Dopamine is an evolutionarily ancient signaling molecule implicated in stress responses across the tree of life. The role of dopamine is well-documented in the nervous system of animals, yet in the early-branching animal lineage of sponges its utility is poorly understood. Arctic marine sponges inhabiting the tidal zone of the White Sea, with fluctuating seasonal ice cover and solute concentrations, exhibit remarkable physiological plasticity, making them ideal models for studying conserved stress-response mechanisms. We investigated the dopamine signaling in two sponge species, Sycon ciliatum (class Calcarea) and Halisarca dujardini (class Demospongiae), using metagenomics, transcriptomics, high performance liquid chromatography, mass spectrometry, molecular docking, and imm

SUBMITTER: Kravchuk OI 

PROVIDER: S-EPMC12665527 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature